Antitubercular Drugs Side Effects

Ethambutol is the most commonly implicated drug. 01102006 Although the major severe side effects were ototoxicity hepatotoxicity neuropsychiatric manifestations and hyperuricemia the incidence of severe side effects was not as high as in the other studies range 51234 7 8.

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Refer your patient to TB center where treatment is available 02.

Antitubercular drugs side effects. Red discoloration of your teeth sweat urine saliva and tears. Two significant issues that require further clarification in Garner et als stimulating paper Promoting adherence to tuberculosis treatment 1 are the impact of medication side-effects on treatment adherence as well as how adherence to tuberculosis. Joint or muscle pain.

Visual impairment peripheral neuritis Ethambutol. They do not need medical attention unless they continue or they interfere with normal activities. This is not a complete list of side effects and others may occur.

13092014 Major Side Effects Discontinue drug therapy 01. Drug-Related Side Effects and Adverse Reactions Eye Diseaseschemically induced. If playback doesnt.

One prominent effect is a reddish-orange discoloration of body fluids such as saliva tears urine and perspiration. Anti-tuberculosis medication side-effects constitute major factor for poor adherence to tuberculosis treatment Niyi Awofeso a. Mild rash or itching.

Toxicity is manifested by impairment of visual acuity marked loss of colour discrimination constricted visual fields and central and peripheral scotoma. 30062021 Common side effects may include. Degeneration of the optic chiasma and nerve is a well-known adverse effect of ethambutol.

Total complication rate due to anti-TB drugs were 57 events with low life-threatening complications. A severe side effect of antitubercular therapy. Nausea vomiting stomach pain.

MNEMONICS -ANTITUBERCULAR DRUGS AND THEIR SIDE EFFECTS ATT DRUGS ADVERSE EFFECTS. Dizziness feeling faint weak or unsteady. It is not dangerous but can be disturbing to the patient due to its cosmetic effects 2.

The Important Side Effects of Anti-Tubercular Drugs Isoniazid INH Hepatotoxicity B6 deficiencies Peripheral neuritis Cutaneous hypersensitivity Rarely can cause optic neuritis Isoniazid is also associated with drug-induced lupus erythematosus Rifampin RMP Hepatotoxicity Nephrotoxicity Red discoloration of the body fluids which may be alarming but is completely benign Flu. The gastrointestinal side effects of PAS are so frequent that PAS is no longer used as a primary drug in adults. Jaundice yellowish discoloration of urine eye and body Most anti- Drugs.

These problems usually go away as the body adjusts to the medicine. Given the increasing prevalence of tuberculosis antitubercular drugs frequently used are also associated with ocular toxicity. As shown in Table 1 of our article drug dosage was adjusted for body weight as recommended 1 2 5 and was not associated with toxicity.

Children appear to tolerate PAS much better than adults although hypersensitivity reactions such as fever rash and arthritis have been reported. Gonadal Steroid Hormonesadverse effects. Adverse Drug Effects and Drug Interactions Listed by Drug 19-48 amikacin 20-21 capreomycin 22-23 clofazimine 24-25 cycloserine 26-27 ethambutol 28-29 ethionamide 30-31 isoniazid 32-34 kanamycin 20-21 levofloxacin 40-41 ofloxacin 40-41 para-aminosalicylic acid 36-37 pyrazinamide 38-39 rifampin 42-45 rifabutin 46 rifapentine 47 streptomycin 20-21 Tables.

As demonstrated in Figures 2 and 3 of our article almost all adverse events occurred in the first 2 months of therapy. 14072021 Other rare side effects include. For example none of those patients with drug.

18082015 Adverse Reactions harmless orange color to urine sweat and tears Occasional adverse effects include rashes thrombocytopenia and nephritis rashes thrombocytopenia and nephritis cholestatic jaundice and occasionally hepatitis light-chain proteinuria flu-like syndrome characterized by fever chills myalgias anemia and thrombocytopenia. Refer your patient to TB center where treatment is available 03. It is generally well tolerated but known to cause optic neuritis more specifically retro bulbar neuritis causing blurred vision decreased visual acuity central scotomas and loss of red-green color vision.

As we reported few of the patients with serious adverse events had comorbid conditions. Less serious side effects such as dizziness nausea or vomiting appetite loss sore mouth or metallic taste may also occur. Call your doctor for medical advice about side effects.

Rifampin is an anti-tuberculosis agent with a wide array of side effects. 26022015 Adverse Effects one of the most unpleasant of anti tubercular drugs Gastrointestinal hypothyroidism especially when given in combination with PAS hypoglycaemia in diabetic patients 47.

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