Ocular Side Effects Of Antitubercular Drugs Ppt

ALT 10-20 of the patients Hepatitis 21 over all incidence 27 with RIF. Among ATT ethambutol is the most commonly implicated drug causing optic neuropathy.

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It is generally well tolerated but known to cause optic neuritis more specifically retro bulbar neuritis causing blurred vision decreased visual acuity central scotomas and loss of red-green color vision.

Ocular side effects of antitubercular drugs ppt. -- Short ocular contact time Short ocular contact time - Imprecise and inconsistent deliveryImprecise and inconsistent delivery. Other side effects Hemolytic anemia Seizures Psychosis Lupus-likesyndrome INH Hepatic transaminase AST. Antitubercular drugs are frequently associated with ocular toxicity.

Ocular TB or side-effects of anti-TB therapy. Bastion ML1 Kok HS Muhaya M. India is among the countries that carry the highest burden for tuberculosis.

18082015 Adverse Effect Hepatotoxicity in15 of patients less common in Indian population Nausea vomiting drug fever and hyperuricemiahyperuricemia. Ocular toxicology is dependent on the concentration of the drug frequency of application speed of removal and whether the drug reaches sensitive cells such as the corneal endothelium lens epithelium or. Antituberculosis drugs may produce side effects varying from unimportant to life-threatening.

1Department of Ophthalmology Faculty of Medicine Universiti Kebangsaan Malaysia Hospital Universiti Kebangsaan. Ototoxicity is a well known problem caused by streptomycin kanamycin capreomycin and viomycin. On the other hand for posterior ocular delivery research has been immensely focused towards development of drug releasing devices and nanoformulations for treating chronic vitreoretinal diseases.

Block Histamine-1 H1 receptors. 22092015 Pyrazinamide Z Adverse effects Hepatotoxicity Hyperuricaemia Other adverse effects are abdominal distress arthralgia flushing rashes fever and loss of diabetes control. These novel devices andor formulations may help to surpass ocular barriers and associated side effects with conventional topical drops.

Ocular Side Effects. For assessing spectrum of ATT induced ocular toxicity clinical presentation monitoring and preventive measures a prospective observational follow up study was conducted. 20 yo very rare 3 x higher in those over 35 4 x higher if daily alcohol in one study 42 of cases were fatal Isoniazid -ADR.

Kokkada SB Barthakur R Natarajan M et al. Repeated blood glucose monitoring is warranted in diabetics. The side effects of drugs prescribed for a patient must be known as well as whether it is necessary to monitor for such effects.

Ethambutol is the most commonly implicated drug. Contact lens intolerance. Occurs uniformly drug therapy should be not stopped Contraindicated in liver disease patient.

Toxicity is manifested by impairment of visual acuity marked loss of colour discrimination constricted visual fields and central and peripheral scotoma. Kathmandu Univ Med J. Claritin Loratadine Zyrtec cetirizine Allegra fexofenadine Benadryl Diphenhydramine HCl Sudafed pseudoephedrine Mechanism of Ocular Side Effects.

Systemic drug-induced ocular side effects are increasing due to the large number of new drugs now available Increased use of chemotherapeutic agents has resulted in longer patient survival potentially resulting in the ophthalmologist seeing more patients with ocular side effects. Myambutol ethambutol package insert. Side effects.

Cause anesthesia and akinesia for intraocular surgery. Table 1 lists the side effects and recommendations for monitoring of antituberculosis drugs used in the United States. Degeneration of the optic chiasma and nerve is a well-known adverse effect of ethambutol.

Antitubercular drugs hv side effects on pregnancy Side effect of antitubercular drugs ppt Side effects of antitubercular drugs bleeding gums. Optic neuropathy has been reported as a side effect of long-term use of linezolid. Drug eliminating mechanismsDrug eliminating mechanisms Lacrimal gland Tear production.

Ocular side effects of antitubercular drugsa focus on prevention early detection and management. Adverse Drug Effects and Drug Interactions Listed by Drug 19-48 amikacin 20-21 capreomycin 22-23 clofazimine 24-25 cycloserine 26-27 ethambutol 28-29 ethionamide 30-31 isoniazid 32-34 kanamycin 20-21 levofloxacin 40-41 ofloxacin 40-41 para-aminosalicylic acid 36-37 pyrazinamide 38-39 rifampin 42-45 rifabutin 46 rifapentine 47 streptomycin 20-21 Tables. For assessing spectrum of ATT induced ocular toxicity clinical.

Drug delivery to the eye is a complex process. Dry Eye Keratitis sicca. 112 2 l minl min.

Among ATT ethambutol is the most commonly implicated drug causing optic neuropathy. Ethambutol E Tuberculostatic Fast multiplying bacilli are more susceptible. Given the increasing prevalence of tuberculosis antitubercular drugs frequently used are also associated with ocular toxicity.

Angle closure glaucoma or Narrow angle glaucoma. 14 ANTI-ALLERGY AGENTS. This is particularly seen in cases of drug resistant tuberculosis where treatment with linezolid may continue for about 18-24 months Educating the patients for early detection of the ocular manifestations and regular follow-ups are very essential.

Antitubercular drugs are frequently associated with ocular toxicity. It is the biological and therapeutic effect of the drug mechanism of action.